Monkey on Their Backs
Monkey on Their Backs was an anti-heroin PSA created in the early 70s. It first shows a wind-up monkey crashing its cymbals as a little girl's voice says, "They say that people on heroin had a monkey on their back. Isn't it cute?". Suddenly, the wind-up monkey stops playing as the camera zooms in to the monkey's face, which switched to a still of a real screaming monkey with a loud primate scream, and white text appears reading "Why do you think they call it DOPE?". It was the first screamer in the world ever made, with Kikia being the first one uploaded.
NOTE: The following video contains a screamer.